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ERAD as a central metabolic checkpoint: the Sel1L-HRD1 axis Among ERAD components, the Sel1L-HRD1 complex is highly conserved across species and has emerged as a central regulator of systemic metabolism, influencing diverse processes ranging from appetite control to lipid handling and insulin secretion

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One shot of the injection costs Ksh50,000, putting it out of reach for the very populations most burdened by diabetes and obesity