Clinicians should monitor patients for potential adverse effects including pancreatitis (severe, persistent abdominal pain), gallbladder disease (right upper quadrant pain), diabetic retinopathy complications (especially with rapid glucose improvement), acute kidney injury with dehydration, and hypoglycemia when combined with insulin or sulfonylureas
GLP-1 agonists affect diverse obesity etiopathogenic processes such as abnormal food intake regulation, adipocyte dysfunction, insulin resistance, adipokine production, inflammation, endothelial dysfunction, lipid metabolism, and oxidative stress
This is consistent with the characteristics of patients deficient in the POMC-MC4R pathway [5]
In rodents, -cell replication increased by 2.8-fold after partial pancreatectomy [4] and by 2.5-fold during pregnancy [5]
Important remind: A higher dose is NOT always better