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Peripheral Polyneuropathy For the most part, the published evidence base describes B12 as a treatment for pain in peripheral polyneuropathies with fifteen studies addressing this topic

It has been studied primarily in animal models for wound healing, tissue repair, reduction of inflammation, and recovery from cardiac injury

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[1] [3] A family of histone deacetylases known as sirtuins (Sirt 1-7) controls a number of proteins involved in cellular metabolism, stress responses, circadian rhythms, and endocrine functions

Some users prefer keeping them in separate vials to maintain individual dose flexibility