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The hazard-ratios [95% CI] of the composite kidney outcome with GLP-1 RAs versus basal insulin were 0.96 [0.821.11] (p = 0.566) and 0.71 [0.540.95] (p = 0.020) in the ITT and AT analyses, respectively

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To mechanistically determine whether 15LO1 pathway activation alters the intracellular redox balance, particularly under T2 conditions, these ex vivo findings were modeled in vitro in primary HAECs

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Most patients begin with a 0.25 mg dose in week one, then progress through 0.5 mg, 1.0 mg, 1.7 mg, and up to 2.4 mg maintenance depending on tolerability and clinical response