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In animal models (rats), its effects on the nitric oxide (NO) pathway through modulation of NO synthase (eNOS) expression have been described

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PMID: 15666314 Bker T, Vanem TT, Pripp AH, Rand-Hendriksen S, Paus B, Smith HJ, Lundby R

Additionally, certain nanocarriers still face payload limitations- while NLCs improved capacity over solid lipid nanoparticles, some highly bioactive nutraceuticals require even higher loading or multiple compound co-entrapment, pushing existing techniques to their limits (189193)

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