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The ideal frequency varies based on your individual needs

Medication discontinuation : If topiramate needs to be stopped, it should be gradually tapered rather than abruptly discontinued to reduce the risk of seizures, even in patients without epilepsy

Western blot assay Gastrocnemius muscles were collected for the detection of NLRP3, GSDMD-FL, GSDMD-N, IL-1, IL-18, CD31, and VEGF-, while HUVECs and THP-1 cells were collected for the detection of GSDMD-FL, GSDMD-N, IL-1, IL-18, and CCL11

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Mantle D, Hargreaves IP, Domingo JC, Castro-Marrero J