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It should be used under medical supervision

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IGF-I is also produced by most, if not all, tissues and acts in an autocrine-paracrine mode [4]

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Lancet 1:200204 Dahl-Jrgensen K, Brinchmann-Hansen O, Hanssen KF, Sandvik L, Aagenaes O (1985) Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study