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Infiltrating leukocytes such as tumor associated macrophages (TAMs), neutrophils, dendritic cells, and lymphocytes establish an inflammatory microenvironment and are key components in tumors of epithelial origins

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Beyond injury or infection, there's the risk of the pigment causing visual obstructionremember, your pupil is an aperture that opens and closes when reacting to light or other stimuli. She also points to the possibility of an allergic reaction to the pigments