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49 A deficit in the tricarboxylic acid cycle and ETC function under conditions of excessive superoxide production in the brain would be expected to result in a reduced ability to maintain adequate levels of ATP required for normal neuronal and synaptic functioning

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Experiments indicate that paeonol markedly impedes IL-1-induced ferroptosis and inflammation in chondrocytes, partly through the AMPK/Nrf2/GPX4 axis ( in vitro and in vivo to alleviate DMM-induced OA