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Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies

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Vitamin A deficiency [2] Causes Disorders associated with fat malabsorption: inflammatory bowel disease (e.g., Crohn disease), celiac disease, cystic fibrosis, pancreatic insufficiency, cholestasis [3] Malnutrition: most common cause of vitamin A deficiency in developing countries Clinical features Ocular manifestations Night blindness (nyctalopia) Retinopathy Xerophthalmia Keratomalacia Bitot spots: gray, triangular, dry patches on the bulbar conjunctiva, covered by a layer with a foamy appearance Typical sign of vitamin A deficiency Caused by squamous cell metaplasia and keratinization of the conjunctiva Keratinizing squamous metaplasia of the bladder (pearl-like plaques on cystoscopy) Xerosis cutis Immunosuppression: Vitamin A deficiency increases the risk of a measles infection taking a severe course