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After one week, these devices were wirelessly controlled using a radio-frequency power source to activate cholinergic terminals in the small intestine with a 473 nm laser (25 mW, 50 Hz)
We start at a low dose and increase slowly to minimize side effects
Most clinical protocols follow a step-up schedule every four weeks, beginning at 2 mg and moving toward 4 mg, 8 mg, and potentially 12 mg depending on tolerability and response
The GLP-1 receptor activation in the hypothalamus directly reduces hunger signals
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