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Key variants in genes like GLP1R (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) may influence how a person's body processes GLP-1 medications and responds to dose adjustments

Hypoglycemia represents a serious acute risk, as IGF-1 DES possesses potent insulin-like metabolic effects including enhanced glucose uptake into muscle and adipose tissue, increased glycogen synthesis, and suppression of hepatic glucose output

In patients with persistent hyperglycaemia, in particular those without weight concerns, consideration could be given to commencing insulin therapy meanwhile

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