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Moreover, Yusta et al., used a DSS colitis model in GLP-1R knockout (GLP-1R KO) mice to assess the significance of GLP-1 signaling in a localized inflammatory context

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1 Smaller amounts of GLP-1 are also produced by neurons in the nucleus tractus solitarius (NTS) of the brainstem, thus highlighting its dual role in both peripheral and central metabolic regulation

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Its a hormone naturally produced by the body and plays a vital role in everyday metabolic function