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The amygdala hyperactivation, excessive sympathetic nervous system arousal, and impaired fear extinction that characterize anxiety disorders respond to different peptide targets than the anhedonia, BDNF deficits, and hippocampal atrophy more central to depression

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In a longitudinal study of perimenopausal women with annual indirect calorimetry testing for 4 years, whole-body fat oxidation decreased by 32% in women who became postmenopausal but was unchanged in women who remained premenopausal (61)

Patients who failed to meet specific glycemic goals during the study were treated with glipizide (or other sulfonylurea) rescue