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654 Of note, astrocyte-specific deletion of mutant huntingtin in mice globally expressing this gene eased disease symptoms and delayed its progression, indicating a role for astrocytes in the pathophysiology of the disease
Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K
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Transforming growth factor beta type 1 (TGF-) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells