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Gonzlez-Molina V, Mart-Pineda A, Gonzlez N

On each day, participants were randomised to receive a bolus infusion of metformin (1000 mg in 50 ml 0.9% saline) via a nasoduodenal catheter at t = 60, 30 or 0 min (and saline at the other timepoints) or saline at all timepoints (control), followed by an intraduodenal glucose infusion of 12.56 kJ/min (3 kcal/min) at t = 060 min

Understanding its mechanism and approval process can provide a clear picture of its utility in weight management

The choice of medication should be based on discussions and individualized guidance from a healthcare professional who has a comprehensive understanding of your medical condition

Patients already on GLP-1 therapy for metabolic syndrome or obesity may still benefit from tesamorelin if a GH-axis component is contributing to their visceral fat though combination use requires careful clinical evaluation