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These results shed light on the role that GIP receptor agonism plays in the therapeutic profile of dual receptor agonism and provide mechanistic explanations for the clinical effectiveness of tirzepatide [80]

+ -glucose transporter 2 (SGLT2), which couples the transport of the sugar with that of Na + following its electrochemical gradient created by the Na + /K + ATPase on the basolateral membrane of the tubular cells (see Figure 3B)

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