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Among the drugs facing loss of exclusivity: Mercks Keytruda, a cancer immunotherapy with over $29 billion in 2024 sales, facing loss of exclusivity in 2028

Higher baseline risk: People with diabetes already face an increased risk of gum disease and slow healing

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In clinical settings, several trialsnotably the longer one, with sitagliptindid not show an increased risk for ischemic events [60], but the encouraging results from basic science were not yet translated into clinical evidence, probably due the pleiotropic enzymatic effects of DPP4 [159, 160]

If your blood sugar is dangerously elevated, you need therapeutic doses under close medical supervision