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Astrocyte-mediated regulation of CBF Perivascular astrocytes, located near synapses, are stimulated by neuronal activity, while their end-feet envelop blood vessels and communicate with SMCs and pericytes, which regulate CBF

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Chronic is the operative word: it is designed and labeled for ongoing, long-term use, consistent with treating obesity as a chronic disease

Symptoms of an overdose may include nausea, vomiting, diarrhea, and low blood sugar

In some cases, temporary dose reduction or slower titration may resolve sleep issues while maintaining therapeutic benefits