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Experimental models of anoxia/reoxygenation injury demonstrated that larazotide preserves epithelial barrier integrity by maintaining transepithelial electrical resistance and preventing the disassembly of tight junction components such as ZO-1, occludin, and claudins

This is expected and does not necessarily indicate a problem, but monitoring during the transition is important

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We established downstream signaling cascades for the first time, including FGF5 , FGFR1 , androgen, AR , Wnt/-catenin , Shh/Gli2 , c-MYC , and KRTs