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doi:10.18632/oncotarget.11168 Ma WH, Li M, Ma HF, et al

Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes

This regulatory mechanism may stem from its detergent-like effect, which affects the structure and function of the cell membrane [122]