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When loaded on scaffolds such as collagen sponges and treated dentin matrix (TDM) and subsequently implanted into bone defects, NAC or NAC-pretreated MSCs can significantly enhance collagen deposition, bone formation rate, bone volume/total volume (BV/TV), bone mineral density (BMD) and trabecular bone parameters (thickness, number, separation)

Subsequent research has extended these findings to broader metabolic populations, with some studies reporting reductions of up to 20% in abdominal fat over a 6-month research period