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Earlier Inpatient Study An uncontrolled study included people admitted for alcohol or opioid withdrawal

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This impairment mainly involves the System Xc /GSH/ GPX4 axis and nuclear factor erythroid 2-related factor 2 ( NRF2) -dependent transcriptional network ( System Xc ( SLC7A11 / SLC3A2 ) takes up cysteine to synthesize GSH( GPX4 to reduce phospholipid hydroperoxides ( activity leads to GSH consumption ( NRF2 plays a central role in maintaining cellular redox balance and limiting ferroptosis