For exenatide immediate-release, other oral medicines that require complete absorption (such as contraceptives and antibiotics) should be taken at least 1 hour before the injection, as the slowing of gastric emptying may affect their absorption
Other concerning symptoms that necessitate medical consultation include: Severe abdominal distension or inability to pass gas/stool (possible ileus or bowel obstruction) Nausea that worsens rather than improves after 812 weeks Inability to maintain adequate nutrition or hydration Unintentional weight loss exceeding clinical targets New or worsening heartburn or reflux symptoms Visual changes (especially with rapid blood sugar improvement) Severe headache or altered mental status Signs of gallbladder disease (right upper quadrant pain, especially after eating) Hypoglycemia symptoms if taking insulin or sulfonylureas Patients should generally not discontinue GLP-1 medications without medical guidance, except in emergencies such as suspected pancreatitis or severe allergic reaction
In contrast to RCTs, retrospective observational studies offer the benefit of capturing extensive patient data in real-world settings
And most importantly, they want real and sustainable results
Prather says these medications impact on weight loss and, thereby, reduced systemic inflammation could become an important tool for treating patients at high risk due to poor type 2 diabetes control and obesity before surgeryor even helping them to avoid surgery in the first place
