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Semaglutide treatment decreases stroma development and allows T lymphocyte infiltration in ex vivo and in vivo models of PDAC developing upon metabolic syndrome To further explore the active role of P4HA1 role in stroma development, data related to P4HA1 and immune cell signature [55] gene expression levels of PDAC patients deposited in TCGA data portal were correlated, revealing that P4HA1 expression enrichment associates with decreased T lymphocyte signature expression (Fig