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Hepatocellular carcinoma progression is driven by pathological angiogenesis and an immunosuppressive microenvironment

Research has demonstrated that GA modulates the AMPK/SREBP/ACC and IRs-1/Akt signaling pathways, which are pivotal in cellular metabolism, and it also suppresses liver inflammation by targeting the IKK/i-B/NF-B signaling pathway, a key mediator of inflammatory responses ( Previous studies on the mechanism of action of GA on NAFLD were based on pharmacological methods

Seiwerth S, Brcic L, Vuletic L, Kolenc D, Aralica G, Misic M, et al

175 Currently, GSBR-1290 is undergoing a 12-week Phase 2a randomized, double-blind, placebo-controlled clinical trial to assess its effectiveness in treating patients with T2DM and obesity