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By inhibiting osteoblast differentiation of VSMCs, GLP-1RAs can ameliorate phosphate-induced vascular calcification, which is mediated by the AMPK/mTOR pathway or AMPK/receptor activator of nuclear factor kappa B ligand (RANKL), as occurs in the osteoblast differentiation of VSMCs [128, 129]

Patients should be counselled that these effects are expected, generally transient, and often improve with continued treatment, though persistent or severe symptoms warrant medical review

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Redox Signal 22 (8), 679685

100 56-162 L-