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As of February 2025, Ozempic (semaglutide) remains FDA-approved for two uses: To improve blood sugar control in adults with type 2 diabetes, combined with diet and exercise

What stood out was the lack of major difference between agents, suggesting that while GLP-1-based therapies as a class have a relatively higher risk of [GI] events compared with other glucose-lowering drug classes, there do not appear to be substantial safety differences within the class itself, Alkabbani told Healio

Both tirzepatide and semaglutide lower blood glucose through multiple mechanisms, and the transition period creates temporary fluctuations that need active management

Rybelsus can slow your digestion, and it may take longer for your body to absorb any medicines you take by mouth

Staying hydrated and reporting persistent GI symptoms early are the best protections