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Finally, species captured by our differential abundance analysis were channeled into a GFLASSO model with the fecal metabolome library to select metabolically relevant compounds best predicted by microbial abundances

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GLP-1 is rapidly degraded with a half-life of less than two minutes by dipeptidyl peptidase-4 (DPP-4) in humans [53]

4.2.2 Glutathione peroxidase 4 (GPX4) GPX4 is a crucial enzyme inhibiting ferroptosis, protecting cell membranes from oxidative damage by reducing lipid peroxides

The effects of ferroptosis in the fibrocartilage of the TMJ and the hyaline cartilage of the knee exhibit both similarities and potential differences, which can be attributed to the distinct tissue characteristics and microenvironments of these two joint types