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The dilution of the ELF was calculated by measuring urea in both the BAL fluid (BALF) and plasma as previously reported [16]

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In a hemophilia dog model, there was evidence of AAV integration four years after being treated with canine factor VIII (cFVIII) in an AAV8/9 vector, however, there was no evidence of tumor formation within these dogs that had AAV integration [151]

* **Reduccin de la inflamacin:** El cobre puede tener propiedades antiinflamatorias, ayudando a calmar la piel y reducir el enrojecimiento