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DKD replaced the older term, diabetic nephropathy, which referred to specific glomerular lesions of nodular glomerulosclerosis and glomerular basement membrane thickening, because of emerging evidence for a variety of other types of structural kidney injury caused by DM

And some people may be more likely to experience serious side effects on GLP-1s, including people with kidney or gallbladder problems or diabetic retinopathy

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Hydrochlorothiazide: In a pharmacokinetic interaction study, coadministration of multiple-dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%