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However, increased oxidative stress (due to UA-induced ROS production from endothelial cells, vascular smooth muscle cells, macrophages and blood-born cells, like monocytes) and pro-inflammatory state induced by the presence of UA within the atherosclerotic plaques promote atherosclerotic plaque propagation and instability

Nandi A, Yan LJ, Jana CK, et al

However, during other metabolic activities, NAD+ is consumed by NAD+-dependent enzymes and may subsequently become depleted over time, contributing to increased DNA damage, age-related illnesses and diseases, and mitochondrial malfunction

I recommend supplementing with a high-quality vitamin D3 supplement to get your levels between 50-100 ng/mL