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Dickkopf-related protein 3 (DKK-3) is a glycoprotein secreted upon tubular injury that promotes scarring that significantly predicts estimated glomerular filtration rate (eGFR) decline and identifies patients at high risk of CKD progression 187
[] The potential kidney-protective mechanisms of GLP-1 RAs are still under investigation, and findings from the FLOW trial support the role of once-weekly subcutaneous semaglutide in slowing kidney function decline and reducing cardiovascular mortality in patients with T2D and CKD
Curr Pharm Biotechnol (2023) 24:144964
In addition, it includes comparisons of approved drugs, late-stage drugs and emerging oral obesity drugs
10.1016/j.jnutbio.2017.02.016 J
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