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There is some limited support for other effects, but more research is needed

PMID: 40 ZangSWangLMaXZhuGZhuangZXunYet al

Tirzepatide also demonstrated favorable effects on lipid profiles, blood pressure, and biomarkers of insulin sensitivity and liver function.The most common adverse events reported with tirzepatide and semaglutide were gastrointestinal in nature, including nausea, diarrhea, and vomiting, which were mostly mild to moderate in severity

J Clin Psychiatry 2026;87(3):26com16484 Submitted: April 17, 2026

For acute metabolic effects and rapid assessment: An 8-week cycle with a 4-week washout is the appropriate starting structure