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This suggests that semaglutides cardioprotective mechanisms extend beyond weight reduction, potentially involving anti-inflammatory effects, improvements in endothelial function, blood pressure, and lipid modulation, or direct vascular and central nervous system pathways, although these mechanisms were not directly tested in this analysis
When B12 is insufficient, these pathways slow down
or a BMI of 27 or higher coupled with conditions like hypertension, type 2 diabetes, or hypercholesterolemia
Sep 24 2020;25(19)doi:10.3390/molecules25194382 Strikwerda AJ, Dommershuijsen LJ, Ikram MK, Voortman T