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If your body aches are severe, worsening after the first week, or accompanied by swelling, warmth, or redness in specific joints, contact your healthcare provider to rule out infection or inflammatory conditions unrelated to the medication

PhD Thesis, The University of Texas at Austin (2014)

In short, the default mode often operates as a mental simulator, engaging whenever attention drifts and running simulations of what is next on the agenda, what could go wrong, or what is already wrong and needs to be fixed

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PMID: 19891010