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NLRP3 is also considered a key regulator of intestinal inflammation in humans, as exemplified by conditions such as Crohns disease

In particular, the use of anti-CTLA4 antibodies has been associated with the development of autoimmune hypophysitis, where only a small number of patients may discontinue glucocorticoid replacement after ICI therapy due to irreversible pituitary damage (67)

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Besides macrophages, monocytes can also be affected by uremic toxins

Research suggests that certain mycotoxins can actually interfere with the enzymes needed to create new glutathione