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The analyses were performed on a Q-Exactive Plus mass spectrometer

Time-lapse microscopy of ESA-treated BT549 cells (Supplementary Movie 1) showed that during the latter part of 24 h of treatment, otherwise healthy appearing cells undergo a sudden death, morphologically similar to cell death by the canonical ferroptosis inducer ML162 (Supplementary Movie 2) and distinct from apoptosis (Supplementary Movie 3)

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It was suggested that certain combinations, particularly at a GHK-Cu to LMW HA ratio of 1:9, appeared to have significantly boosted the synthesis of collagen IVmore so than when either compound was studied independently

Identification of Key Amino Acids Responsible for the Substantially Higher Affinities of Human Type 1 3-Hydroxysteroid Dehydrogenase/isomerase (3-HSD1) for Substrates, Coenzymes, and Inhibitors Relative to Human 3-HSD2