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In the breast cancer lung metastasis model, the platelet-derived growth factor C (PDGF-C) level in the microenvironment increases when lung tissue becomes senescent or fibrotic

44,45 In oesophageal squamous cell carcinoma, miR-455-3p participates in the activation of canonical Wnt signalling by simultaneously targeting and inhibiting multiple negative regulatory factors (e.g., DKK3 and GSK3) of the Wnt/-catenin signalling pathway