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HT-1080 Control N -treated with DMSO or nutlin-3b: 1,0001,500, MDM2 inhibitors: 3,0004,000, or gemcitabine: 3,0004,000

Cell culturing The T24 human bladder cancer cell line (Bio-73168, Chinese Microbial Culture Collection, Beijing, China) was obtained from the Chinese Microbial Culture Collection

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This dual action results in improved postprandial and fasting glucose levels, along with significant reductions in body weight