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Serious hypersensitivity, acute kidney injury from dehydration, and diabetic retinopathy considerations are also documented in the label

One study found that within one year, 46.5% of those with diabetes and 64.8% of those without had ceased the drug

By contrast, tesamorelin's N-terminal trans-2-hexenoic acid modification addresses a different problem: GHRH has a short half-life in vivo due to dipeptidyl peptidase IV cleavage at the Tyr1-Ala2 bond