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According to FDA prescribing information, semaglutide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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Our findings support an association between use of semaglutide for type 2 diabetes and risk of non-arteritic anterior ischemic optic neuropathy, with a more than two-fold increased hazard ratio, Professor Pottegrd explained

This dosing approach helps minimize the risk of adverse events, particularly severe gastrointestinal concerns, which are expected during the beginning of the therapy