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Therapeutic strategy of IR Clinical approved treatment to IR No medications exist currently that are specifically approved to treat IR, but IR management 91,448,449 is possible through lifestyle changes like dietary, increased exercise, and disease prevention in addition to alternative medications (Fig

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Another option gaining attention is tirzepatide, which has shown even higher average weight loss in some trials (sometimes over 20% of body weight)

AST ELISA A mouse Aspartate Aminotransferase (AST) SimpleStep ELISA kit (abcam, ab263882) was used to measure AST in mouse plasma