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Reduced physical activity during flares, fatigue, and the metabolic consequences of chronic inflammation all contribute as well

Meta-analysis resulted in a standardised mean difference (SMD) of -0.18 (95%CI -0.46-0.10) across 199 cases and 185 controls using a random effects model

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Effects in other conditions Five studies focused on the effects of IF on special populations, including individuals in special physiological states, such as during pregnancy or before or after an operation, and individuals with conditions such as polycystic ovary syndrome (PCOS), multiple sclerosis (MS), or chronic myelogenous leukemia (CML) (Table 3)

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