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Semaglutide is the steadier backbone

Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which are typically mild to moderate and often diminish over time

Compared with DPP4i users, semaglutide users experienced more substantial reductions in HbA1c and BMI and reduced risks of treatment augmentation after 2 years of persistent use

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This combination has been suggested as a potential early glucose-lowering treatment of type 2 diabetes due to their complementing mechanism of action (142)