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Research in Obesity shows that patients on GLP-1 drugs who consumed fewer than 80 grams of protein daily lost 15-20% more lean muscle mass compared to those meeting protein targets

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In preclinical and ex vivo models, GLP-1R agonism has been linked to augmented glucose-dependent insulin secretion, suppressed glucagon release from pancreatic alpha cells, and delayed gastric emptying

This receptor-specific selectivity is the mechanistic basis for its pharmacological advantages over GHRP-6, which more closely mimics ghrelins full effect profile