I am not a chemist but B12 does seem to be an inherently stable molecule, not least indicated by the fact that the boxes of it have long shelf from production dates on them
For example, some novel antidepressants function as agonists of the 5-HT 1A , 5-HT 2B , or 5-HT 4 receptor or antagonists of the 5-HT 1B , 5-HT 2A , 5-HT 2C , 5-HT 3 , 5-HT 6 , or 5-HT 7 receptor
Furthermore, there is strong evidence suggesting that lipofuscin (a photoreactive substance) is derived, at least in part, from oxidatively damaged photoreceptor outer segments (Drobek-Slowik 2007)
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Biochemically, due to intracellular GSH deprivation and GPX4 deactivation, lipid peroxides derived from Fe2+-catalyzed Fenton reaction fail to be eliminated through the GPX4-mediated reduction reaction, producing abundant reactive oxygen species (ROS), which facilitates ferroptosis (Stockwell et al., 2017
