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Since the unavailability of crystal structures of OATPs and relative difficulties in validating their homology models, pharmacophore models have helped elucidate the key molecular features involved in the substrate/inhibitor and protein interactions

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10,13 Hypothyroidism can be a cause of infertility and pregnancy complications

(2010) also showed a higher rate of transmethylation of methionine in the late gestation compared to non-pregnant women which may be related to high methylation demands by the growing fetus and the placenta (Reference Obeid, Morkbak and Munz45)