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Some evidence suggests that significant suppression of one pituitary function can sometimes have minor, downstream effects on others

This chronic, interferon-driven inflammation in the gut creates a devastating downstream effect: it severely impairs the intestinal lining's ability to absorb dietary L-tryptophan

82 In type 2 diabetes-associated cognitive impairment animal models and high-glucose in vitro studies, neuroinflammatory markers, such as IL-1 , TNF-, IL-6, and MCP-1, and inflammatory responses, such as toll-like receptor 4, cyclooxygenase 1 (COX1), COX2, NF-B, leukocyte common antigen, and inducible nitric oxide synthase were increased in the brain

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