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ACTL6A is found to be critical for regulating the glutathione (GSH) metabolism pathway because it upregulates -glutamyl-cysteine ligase catalytic subunit (GCLC) expression, thereby reducing reactive oxygen species (ROS) levels and inhibiting ferroptosis, a regulated form of cell death driven by the accumulation of lipid-based ROS

He has served as Medical Director and Advisor to multiple clinical and laboratory organizations and was named Top Medical Consultant of the Year (2020) by the International Association of Top Professionals

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doi: 10.1007/s00240-011-0448-9 70 PizzinoGIrreraNCucinottaMPallioGManninoFArcoraciVet al

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